Water → Cycloheptylmethyl methanesulfonate
反応式
[CH:1]1([CH2:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19].O>ClCCl>[CH3:17][S:18]([O:9][CH2:8][CH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)(=[O:20])=[O:19]参加物
6
実験手順
To a solution of cycloheptylmethanol (1.0 g, 7.81 mmol) in dichloromethane (20 ml) at 0° C. under nitrogen was added triethylamine (1.63 ml, 1.5 mol. equiv.) Methanesulphonyl chloride (0.73 ml, 1.2 mol. equiv.) was added, dropwise, and the reaction allowed to stir for two hours at room temperature. Water (50 ml) and dichloromethane (50 ml) were added. The organic phase was separated, washed with water (2×50 ml) and then dried over anhydrous magnesium sulphate. The solution was then filtered and the solvent removed under reduced pressure to give the title compound as an oil (1.66 g).
後処理
- additionwas added
- customThe organic phase was separated
- washwashed with water (2×50 ml)
- dry with materialdried over anhydrous magnesium sulphate
- filtrationThe solution was then filtered
- customthe solvent removed under reduced pressure
出典と根拠
- ORDレコード
- ord-80caafe921d74b35bf3c6b05b6cddaf8
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05968923
反応ノート
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