Potassium Carbonate → 6-(4-Chlorobenzoyl)-4-(3-hydroxyphenyl)-1-methyl-2(1h)-quinolinone

HRID 1739827ノート

反応式

HRID 1739827 の反応式
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13](=[O:19])[CH:12]=[C:11]3[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26]C)[CH:21]=2)=[O:7])=[CH:4][CH:3]=1.BrB(Br)Br.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13](=[O:19])[CH:12]=[C:11]3[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([OH:26])[CH:21]=2)=[O:7])=[CH:28][CH:29]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 25134Boron tribromideHCID 227143576-(4-Chlorobenzoyl)-4-(3-methoxyphenyl)-1-methyl-2(1h)-quinolinone

生成物 1

HCID 218374946-(4-Chlorobenzoyl)-4-(3-hydroxyphenyl)-1-methyl-2(1h)-quinolinone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Interm. (b 7-g) (6.8 g) was added to DCM (210 ml), stirred at 0° C. Tribromoborane (67.3 ml) was added dropwise and the reaction mixture was stirred at 0° C. for 15 minutes. The mixture was brought to room temperature, stirred at room temperature for 30 minutes and K2CO3 10% was added. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated, yielding 6.6 g of 6-(4-chlorobenzoyl)-4-(3-hydroxyphenyl)-1-methyl-2(1H)-quinolinone (interm. 7-h) (quantitative yield; used in next reaction step, without further purification).

後処理

  1. stirringthe reaction mixture was stirred at 0° C. for 15 minutes
  2. customwas brought to room temperature
  3. stirringstirred at room temperature for 30 minutes
  4. customThe organic layer was separated
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-9ff5f165e57349f69b8cc3dd95260a4a
出典データセット
uspto-grants-1999_10
特許番号
US05968952

反応ノート

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