Methyl 3-(hydroxymethyl)-5-iodobenzoate → Methyl 3-formyl-5-iodobenzoate

HRID 1740306ノート

反応式

HRID 1740306 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([I:13])[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[C:5]([I:13])[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:1]

参加物

4

反応物 1

HCID 21837989Methyl 3-(hydroxymethyl)-5-iodobenzoate

生成物 1

HCID 21838328Methyl 3-formyl-5-iodobenzoate収率 55.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

The mixture of methyl 5-hydroxymethyl-3-iodobenzoate (5.0 g) and manganese dioxide (30.0 g) in ethyl acetate (50.0 ml) was heated under reflux for 4 hours. The magnganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give methyl 5-formyl-3-iodobenzoate (2.77 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customThe magnganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-8198add690444a2cb28721a0145655f5
出典データセット
uspto-grants-1999_10
特許番号
US05968985

反応ノート

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