関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | N,N-Dimethyl-N-decylamine | HCID 70711 | — |
| 溶媒 | Methyl t-butylether hexane | HCID 21982663 | — |
| 生成物 | (3-Chloropropyl)decyldimethylammonium bromide | HCID 85711137 | — |
反応手順
Into a 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged N,N-dimethyldecylamine (200.0 grams, 1.08 moles), 1-bromo-3-chloropropane (170 grams, 1.08 moles) and methanol (200 mL). The reaction was maintained at 65° C. for 18 hours. Solvent was removed by rotary evaporation under reduced pressure and furthermore with high vacuum distillation to yield brown oil. The oil was placed in a beaker and stirred with hexane/t-butylmethylether 1:1 solution (400 mL) causing a white precipitate. The solids were collected by vacuum filtration. Solids were dried in a vacuum oven at 30° C. overnight. Yield 305.0 grams (0.089 moles, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05969090 |
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| 出典データセット | uspto-grants-1999_10 |
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| ORD ID | ord-d1033feccafd4fd0af23433b4b7180af |
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| 出典メモ | uspto-grants-1999_10 |
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