Hydrochloric Acid → Tetrahydropyranyl bromomethyl-cyclohexyl ether

HRID 1740704ノート

反応式

HRID 1740704 の反応式
[Br:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6](O)[CH2:5][CH2:4]1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH2:11]1.Cl.C(=O)([O-])[O-:18].[K+].[K+]>>[Br:1][CH2:2][C:3]1([O:18][CH:15]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 80803,4-dihydro-2H-pyranHCID 11430Potassium CarbonateHCID 218327074-(Bromomethyl)cyclohexan-1-ol

生成物 1

HCID 21832708Tetrahydropyranyl bromomethyl-cyclohexyl ether

実験手順

4-Bromomethylcyclohexanol (C-5) (3.0 g) and dihydropyran (2.6 g) were mixed together and cooled with ice. A tiny drop of 10% hydrochloric acid was added. Exothermic reaction occurred and stirred at ambient temperature overnight. The solution was neutralized with potassium carbonate and extracted with dichloromethane (50 ml). It was filtered and then dichloromethane from the filtrate was evaporated to yield the compound C-6, tetrahydropyranyl bromomethyl-cyclohexyl ether (5.0 g).

後処理

  1. temperaturecooled with ice
  2. customExothermic reaction
  3. extractionextracted with dichloromethane (50 ml)
  4. filtrationIt was filtered
  5. customdichloromethane from the filtrate was evaporated

出典と根拠

ORDレコード
ord-e97403bfc1134ae48d403955498882da
出典データセット
uspto-grants-1999_10
特許番号
US05972552

反応ノート

読み込み中…