Hydrochloric Acid → Iminodiacetic acid
反応式
C([O:8][C:9](=[O:30])[CH2:10][NH:11][CH:12](C(OC(C)(C)C)=O)[C:13]([O:15]CC1C=CC=CC=1)=[O:14])C1C=CC=CC=1.Cl.CCOCC>O1CCOCC1>[NH:11]([CH2:12][C:13]([OH:15])=[O:14])[CH2:10][C:9]([OH:30])=[O:8]参加物
5
実験手順
Boc-Iminodiacetic acid dibenzyl ester (4.5 g, 10.88 mmol) was dissolved in dioxane (15 mL), then 4.6 M HCl in dioxane (20 mL) was added. The mixture was stirred for 90 min at room temperature and Et2O (200 mL) was added. The crystalline product was filtered off, washed twice with Et2O and dried in vacuo to afford the title compound (3.58 g, 94.2%).
後処理
- filtrationThe crystalline product was filtered off
- washwashed twice with Et2O
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-10908730324d424f8aa68cdaba17a4a7
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972926
反応ノート
読み込み中…