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Potassium Hydroxide → 1-Isopropylpiperazine

HRID 1740790
ノート
印刷プレビュー

反応式

HRID 1740790 の反応式
C([N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>CO>[CH:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)([CH3:12])[CH3:11]
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 187964191-[4-(Propan-2-yl)piperazin-1-yl]ethan-1-one

生成物 1

HCID 780131-Isopropylpiperazine収率 105.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 7.26 g of 1-acetyl-4-isopropylpiperazine, 100 ml of methanol and 10 g of potassium hydroxide was heated under reflux for 17 hours. After the solvent was distilled off, water and chloroform were added to perform extraction with chloroform and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 5.78 g of the title compound as an oily substance.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 17 hours
  3. distillationAfter the solvent was distilled off
  4. additionwater and chloroform were added
  5. extractionextraction with chloroform
  6. dry with materialthe extract was dried over anhydrous magnesium sulfate
  7. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-93506c81b4994fe99c541d2a852aa260
出典データセット
uspto-grants-1999_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05972943

反応ノート

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