2-(4-Bromo-2-methylphenyl)-5-methyl-1,3,4-oxadiazole → 2,3'-Dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[C:4]([CH3:14])[CH:3]=1.B([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]=1[CH3:27])(O)O>>[CH3:27][C:19]1[CH:20]=[C:21]([C:22]([OH:24])=[O:23])[CH:25]=[CH:26][C:18]=1[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[C:4]([CH3:14])[CH:3]=1

参加物

反応物 2

HCID 218337622-(4-Bromo-2-methylphenyl)-5-methyl-1,3,4-oxadiazole

HCID 221158924-Borono-3-methylbenzoic acid

生成物 1

HCID 218337632,3'-Dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid

実験手順

The title compound was prepared from 2-(4-bromo-2-methylphenyl)-5-methyl-1,3,4-oxadiazole (D35) and 4-borono-3-methylbenzoic acid (D33) using a similar procedure to Description 11 as a white solid (24%).

出典と根拠

ORDレコード: ord-0433ea6ce8fd487b8a4d8f1d28cb7e17
出典データセット: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05972951

反応ノート

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