Hydrazine, dihydrochloride → HCID 15480333、化合物
反応式
[CH2:1]([CH:3]([C:11](=O)[C:12]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=1[CH3:20])[C:4](=O)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2].Cl.Cl.[NH2:24][NH2:25]>CCO>[CH2:1]([C:3]1[C:11]([C:12]2[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=2[CH3:20])=[N:24][NH:25][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of ethyl 3-ethyl-2,4-dioxo-4-(2,4,6trimethylphenyl)butanoate (6.0 g, 20.7 mmol) and hydrazine dihydrochloride (2.17 g, 20.7 mmoL) in 100 mL of EtOH was stirred at 80° C. for 6 hours. The solvent was then removed from the mixture. 200 mL of water was added to the residue and mixture was neutralized by the addition of solid NaHCO3. The product was extracted into ether. The ether extract was dried over Na2SO4 and evaporated to give 5.8 g as an oil which was used in the next reaction without farther purification.