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Pyridine → N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Dimethyl Sulfide | HCID 1068 | — |
| 反応物 | Chlorine | HCID 24526 | — |
| 反応物 | 4-Bromo-1-methyl-1H-pyrazol-5-amine | HCID 600351 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine | HCID 23303942 | — |
反応手順
A solution of 0.60 mL (8.2 mmol) of dimethyl sulfide in 30 mL of dichloromethane was cooled to -20° C. and 0.50 g (7.0 mmol) of chlorine was added through a sparge tube with cooling and stirring. Subsequently, 1.0 g (5.7 mmol) of 5-amino-4-bromo-l-methylpyrazole and then 1.0 g (12.7 mmol) of pyridine were added with cooling and stirring. A 2 mL aliquot of this mixture was removed and the light yellow solids present were collected by filtration and washed with deuteroacetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05973148 |
| 出典データセット | uspto-grants-1999_10 |
| ORD ID | ord-a70216e9faf0426ea55ddb0fffc328a2 |
| 出典メモ | uspto-grants-1999_10 |