Ethanol → HCID 21835786、化合物

HRID 1741345ノート

反応式

HRID 1741345 の反応式
[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([O:3][CH2:21][CH3:22])=[O:2]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric Acid2 回HCID 19597249HCID 19597249、化合物

生成物 1

HCID 21835786HCID 21835786、化合物収率 73%

実験手順

74.5 g (324.8 mmol) of N-carboxymethylene-4-chloroanthranilic acid are suspended in 1660 g of ethanol, 2.9 g (2.96 mmol) of concentrated sulfuric acid are added and the mixture is heated at the boiling point for 10 hours. After a reaction time of 5 hours, the same amount of sulfuric acid is again added. After 10 hours, the ethanol is distilled off and the product which precipitates out is filtered off in the cold and washed with cold ethanol. 55.5 g (0.22 mol, 73%) of N-carboethoxymethylene-4-chloro-anthranilic acid are obtained.

後処理

  1. temperaturethe mixture is heated at the boiling point for 10 hours
  2. distillationthe ethanol is distilled off
  3. customthe product which precipitates out
  4. filtrationis filtered off in the cold
  5. washwashed with cold ethanol

出典と根拠

ORDレコード
ord-bcafaaa5244e43208bf4d3b96253f486
出典データセット
uspto-grants-1999_10
特許番号
US05973189

反応ノート

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