Sulfuric Acid → HCID 21835783、化合物

HRID 1741347ノート

反応式

HRID 1741347 の反応式
[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([OH:3])=[O:2].S(=O)(=O)(O)O.[CH:21](O)([CH3:23])[CH3:22]>>[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([O:3][CH:21]([CH3:23])[CH3:22])=[O:2]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 19597249HCID 19597249、化合物

生成物 1

HCID 21835783HCID 21835783、化合物収率 78%

実験手順

5 g (21.8 mmol) of N-carboxymethylene-4-chloro-anthranilic acid are suspended in 50 ml of isopropanol, and 222 mg (2.3 mmol) of sulfuric acid are added. The mixture is heated under reflux for 8.25 hours. It is then cooled to room temperature and the product which has precipitated out is washed with petroleum ether and dried. 4.6 g (16.9 mmol; 78%) of N-carboisopropoxymethylene-4-chloro-anthranilic acid are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 8.25 hours
  3. customthe product which has precipitated out
  4. washis washed with petroleum ether
  5. customdried

出典と根拠

ORDレコード
ord-43127324cf9641438ece1bafff033e7a
出典データセット
uspto-grants-1999_10
特許番号
US05973189

反応ノート

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