Boron tribromide → Ethyl 3-(bromomethyl)phenoxyacetate
反応式
O[CH2:2][C:3]1[CH:4]=[C:5]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:2][C:3]1[CH:4]=[C:5]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
To a solution of 3-hydroxymethyl-1-ethoxycarbonylmethoxybenzene (1 g) in dichloromethane (10 ml) was added BBr3 (0.45 ml). After 1 hour, the solvent was evaporated in vacuo and the residue was dissolved in ethyl acetate. The organic layer was washed with NaHCO3 and brine. The dried solvent was evaporated in vacuo to give 3-bromomethyl-1-ethoxycarbonylmethoxybenzene (0.76 g). NMR (CDCl3, δ): 1.29 (3H, t, J=7 Hz), 4.24 (2H, d, J=7 Hz), 4.61 (2H, s), 5.00 (1H, d, J=3.0 Hz), 5.05 (1H, d, J=3.0 Hz), 6.7-7.1 (3H, m), 7.2-7.3 (1H, m)
後処理
- customthe solvent was evaporated in vacuo
- dissolutionthe residue was dissolved in ethyl acetate
- washThe organic layer was washed with NaHCO3 and brine
- customThe dried solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-93b1b64c9a5a44ce8317c9d9c79cee76
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972965
反応ノート
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