Triethylamine → HCID 18660145、化合物

HRID 1741481ノート

反応式

HRID 1741481 の反応式
[OH:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:12])([F:11])[F:10].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[CH3:21][S:22]([O:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:10])([F:11])[F:12])(=[O:24])=[O:23]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

生成物 1

HCID 18660145HCID 18660145、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of the product of step A (1.002 g, 5.08 mmol) and triethylamine (0.78 ml, 5.60 mmol) in CH2Cl2 (50 ml) at -25° C. was added methane sulfonyl chloride (0.40 ml, 5.17 mmol) over a period of 5 min and stirring was continued for 1 hr. The solvent was evaporated in vacuo and the residue purified by chromatography(SiO2, 33% EtOAc in hexanes, elution). The title compound was obtained as a colorless oil.

後処理

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by chromatography(SiO2, 33% EtOAc in hexanes, elution)

出典と根拠

ORDレコード
ord-f35831bc33844711b55c5bae2d3545ed
出典データセット
uspto-grants-1999_10
特許番号
US05972984

反応ノート

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