Carbon tetrabromide → 4-(1-Bromoethyl)benzonitrile

HRID 1741491ノート

反応式

HRID 1741491 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9](O)[CH3:10])=[CH:5][CH:4]=1)#[N:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(OCC)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:32])[CH3:10])=[CH:5][CH:4]=1)#[N:2]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 5833354-(1-Hydroxyethyl)benzonitrile

生成物 1

HCID 218346374-(1-Bromoethyl)benzonitrile

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 1-(4-Cyanophenyl)ethanol 1.01 g, 6.84 mmol), in diethyl ether (15 ml) and triphenylphosphine (2.14 g, 8.17 mmol), was added carbon tetrabromide (2.82 g, 8.50 mmol) in dieathylether (20 ml) at room temperature. After 30 min the reaction was filtered through celite and evaporated to dryness. The residue was purified by chromatography (SiO2, 5% EtOAc in hexanes) to afford the title compound as an oil

後処理

  1. filtrationAfter 30 min the reaction was filtered through celite
  2. customevaporated to dryness
  3. customThe residue was purified by chromatography (SiO2, 5% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-0c1d7562d1dd4bf69493a6ded17bde2b
出典データセット
uspto-grants-1999_10
特許番号
US05972984

反応ノート

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