Methanol → 5'-Chloro-2'-hydroxy-P-acetotoluidide

HRID 1741546

反応式

HRID 1741546 の反応式
CO.[NH2:3][C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([CH3:11])=[CH:6][C:5]=1[OH:12].[C:13](OC(=O)C)(=[O:15])[CH3:14]>O>[Cl:10][C:8]1[C:7]([CH3:11])=[CH:6][C:5]([OH:12])=[C:4]([NH:3][C:13](=[O:15])[CH3:14])[CH:9]=1

参加物

5

反応物 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 1045242-Amino-4-chloro-5-methylphenol

生成物 1

HCID 36474595'-Chloro-2'-hydroxy-P-acetotoluidide収率 70.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 30 ml of methanol, there were added 1.0 g (6.4 mmol) of 2-amino-4-chloro-5-methylphenol and 0.71 g (7.0 mmol) of acetic anhydride and stirred at room temperature for 30 minutes. To this solution, there was added 60 ml of water. The crystals thus precipitated were filtered and recrystallized from methanol. Thus 0.89 g (4.5 mmol) of N-(5-chloro-2-hydroxy-4-methylphenyl)acetamide was obtained as pale brown crystals. The yield was 70%.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere filtered
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-6ea64157d7f44c07b91511244cb404d4
出典データセット
uspto-grants-1994_08
特許番号
US05334225

関連ノート

読み込み中…