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Triethylamine → O-(+)-menthyl dichlorophosphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | (+)-Menthol | HCID 165675 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | O-(+)-menthyl dichlorophosphate | HCID 12473339 | 99% |
反応手順
A solution of 7.5 g (48 mmol) of (1S, 2R, 5S)-(+)-menthol (Aldrich) and 4.86 g (48 mmol) of triethylamine in 20 ml of toluene was dropped into 7.36 g (48 mmol) of POCl3 at 0° C. The entire solution was stirred for 23 hours at room temperature. The insoluble triethylamine hydrochloride was filtered and the solvent was evaporated. Yield 99%, 31P NMR δ 6.76 (CDCl3). (lit. T. Milobedzki, W. Janczak, Roczniki Chemji 11, 840 (1931)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05334741 |
| 出典データセット | uspto-grants-1994_08 |
| ORD ID | ord-1fad478ae6fa49e19328d42f2e875834 |
| 出典メモ | uspto-grants-1994_08 |