Potassium Carbonate → HCID 10929467、化合物

HRID 1741847ノート

反応式

HRID 1741847 の反応式
[OH:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([C:8]2[CH:9]=[C:10]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1.Br[CH:28]([C:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH:38]([CH3:40])[CH3:39])=[CH:33][CH:32]=1)[CH2:29][CH3:30].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:37]([C:34]1[CH:33]=[CH:32][C:31]([CH:28]([O:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([C:8]3[CH:9]=[C:10]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:11]4[C:16]=3[CH:15]=[CH:14][CH:13]=[CH:12]4)=[O:7])=[CH:25][CH:26]=2)[CH2:29][CH3:30])=[CH:36][CH:35]=1)[CH:38]([CH3:40])[CH3:39]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 10956141Benzene, 1-(1-bromopropyl)-4-(2-methylpropyl)-HCID 11824313Ethyl 4-[1-(4-hydroxybenzoyl)indolizin-3-yl]butyrate

生成物 1

HCID 10929467HCID 10929467、化合物収率 87.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of ethyl 4-[1-(4-hydroxybenzoyl)indolizin-3-yl]butyrate (61 mg), 1-bromo-1-(4-isobutylphenyl)propane (53 mg) and potassium carbonate (72 mg) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 18 hours. The reaction mixture was filtered and the filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid. The organic layer was separated, washed with water and brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel eluting with n-hexane and ethyl acetate (2:1) to give ethyl 4-[1-[4-[1-(4-isobutylphenyl)propyloxy]benzoyl]indolizin-3-yl]butyrate (80 mg) as an oil.

後処理

  1. filtrationThe reaction mixture was filtered
  2. additionthe filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated
  7. customThe residue was chromatographed on silica gel eluting with n-hexane and ethyl acetate (2:1)

出典と根拠

ORDレコード
ord-a80def6471c14d74aa6f4c5d7e62c1d6
出典データセット
uspto-grants-1994_08
特許番号
US05334716

反応ノート

読み込み中…