Hydrochloric Acid → Azetidine-3-carbonyldimethylamide hydrochloride

HRID 17420ノート

反応式

HRID 17420 の反応式
C([N:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:23]>C(O)C.[C].[Pd]>[ClH:23].[NH:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 866308481-Benzhydrylazetidine-3-carbonyldimethylamide

生成物 1

HCID 86630847Azetidine-3-carbonyldimethylamide hydrochloride

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

1-Benzhydrylazetidine-3-carbonyldimethylamide (I-144) (0.24 g, 0.82 mmol) was dissolved in ethanol (10 ml), then 1 N hydrochloric acid (0.90 m, 0.90 mmol) and 10% palladium-carbon (containing about 50% water, 0.10 g) were added, followed by stirring under hydrogen atmosphere for 16 hours. The catalyst was removed by filtration, the solvent was evaporated away under reduced pressure to obtain a mixture containing the entitled compound (0.25 g). This was used in the next reaction as it was.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated away under reduced pressure
  3. customto obtain a mixture
  4. customThis was used in the next reaction as it

出典と根拠

ORDレコード
ord-e8db50c7cb1f455197f28eeffe1f0720
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

反応ノート

読み込み中…