反応式
[CH3:1][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17]C)[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3].CN(C[C@H]1[C@](O)(C2C=CC=C(OC)C=2)CCCC1)C>CCO>[CH3:3][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:1]参加物
4
実験手順
To prepare the (+) enantiomer of the title compound, the reaction was run under the same conditions except that (+)-tramadol as the free base was used instead of the (-)-tramadol to yield 2.8 g of the (+) enantiomer of O-desmethyl tramadol (mp. 242°-3° C.) [α]D25 =+32.2 (C=1, EtOH).
出典と根拠
- ORDレコード
- ord-6fa8701eeca94b1196e05d5011e511a9
- 出典データセット
- uspto-grants-1994_08
- 特許番号
- US05336691
関連ノート
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