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Allylamine → 3-Allylaminopyridin-2-ylsulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allylamine | HCID 7853 | — |
| 反応物 | 3-Fluoropyridine-2-sulfonamide | HCID 19957930 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Allylaminopyridin-2-ylsulfonamide | HCID 19009962 | — |
反応手順
5.28 g of 3-fluoropyridin-2-ylsulfonamide and 18.03 ml of allylamine are stirred for 6 hours in a pressurised vessel at a temperature of 125° C. The reaction solution is subsequently concentrated, the crystallisate obtained is dissolved in methylene chloride and a little acetonitrile, the mixture is purified by chromatography using methylene chloride/ethyl acetate (4:1) as the eluent mixture and silica gel as the carrier material. 5.1 g of 3-allylaminopyridin-2-ylsulfonamide (intermediate No. 2.002) of a melting point of 134°-135° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05336773 |
| 出典データセット | uspto-grants-1994_08 |
| ORD ID | ord-0a4eb1fcc7474ba69b8b25dd5e773c78 |
| 出典メモ | uspto-grants-1994_08 |