Acetic Anhydride → HCID 22755584、化合物
反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[O:11]=[C:7]1[C:8]2[C:4](=[CH:3][C:2]([O:1][C:12](=[O:14])[CH3:13])=[CH:10][CH:9]=2)[CH2:5][CH2:6]1参加物
4
実験手順
To a solution of 5-hydroxy-indan-1-one (1600 mg, 10.8 mmol)in CH2Cl2 (20 mL) at 23° C. were added 4-N,N-dimethylaminopyridine (1830 mg, 15 mmol) and acetic anhydride (1500 mg, 1.4 mL, 15 mmol). The reaction mixture was stirred for 25 hours, quenched with 10% hydrochloric acid (HCl) (20 mL) and diluted with CHCl3 (500 mL). The organic layer was separated and washed with saturated aqueous NaHCO3 (20 mL), dried (MgSO4)and concentrated in vacuo. 1H NMR (250 MHz, CDCl3): d 7.78 (d, 2 H), 7.21 (s, 1 H), 7.10 (d, 1 H), 3.28 (t, 2 H), 2.75 (t, 2 H), 2.38 (s, 3 H).
後処理
- customquenched with 10% hydrochloric acid (HCl) (20 mL)
- additiondiluted with CHCl3 (500 mL)
- customThe organic layer was separated
- washwashed with saturated aqueous NaHCO3 (20 mL), dried (MgSO4)and
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-ccc6c823affb4316b18a9da832488e97
- 出典データセット
- uspto-grants-1994_08
- 特許番号
- US05338740
反応ノート
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