Hydrochloric Acid → 2-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride

HRID 1742510ノート

反応式

HRID 1742510 の反応式
C([NH:3][C:4]([CH3:21])([CH:18]([CH3:20])[CH3:19])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6])=O.[ClH:22]>CO.O>[ClH:22].[NH2:3][C:4]([CH3:21])([CH:18]([CH3:19])[CH3:20])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 146957572-formamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide

生成物 1

HCID 200898702-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A suspension of 2-formamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide (99.4 g, 0.318 mols) in 500 mL of methanol, 500 mL of water, and 500 mL of aqueous HCl 10% is heated at 80° C. until all the solid has dissolved (one hour). The reaction mixture is concentrated to 1/3 of the volume and the resulting precipitate is filtered off. After drying the title product is obtained as a white solid, having mp 161°-165° C.

後処理

  1. dissolutionhas dissolved (one hour)
  2. concentrationThe reaction mixture is concentrated to 1/3 of the volume
  3. filtrationthe resulting precipitate is filtered off
  4. dry with materialAfter drying the title product
  5. customis obtained as a white solid

出典と根拠

ORDレコード
ord-9fbcd19f582346e990ee7397b01f72e3
出典データセット
uspto-grants-1994_08
特許番号
US05338883

反応ノート

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