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Benzyl Alcohol → Benzyl anthranilate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Isatoic Anhydride | HCID 8359 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Benzyl anthranilate | HCID 522771 | — |
反応手順
A mixture of isatoic anhydride (8.54 g), benzyl alcohol (6.0 g), 4-dimethylaminopyridine (6.7 g), dimethylformamide (17 ml), triethylamine (5.28 g), and methylene chloride (160 ml) is refluxed overnight, diluted with an equal volume of ethyl acetate and washed with water, brine, and water. The organic solution is dried over magnesium sulfate, filtered, and concentrated in vacuo. The crude product is purified by flash chromatography eluting with 30% ethyl acetate in hexane to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05340801 |
| 出典データセット | uspto-grants-1994_08 |
| ORD ID | ord-5b7fd9a50c3f42d58fe6793f43f34b9b |
| 出典メモ | uspto-grants-1994_08 |