5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid → 5-Amino-7-[cis-3-amino-4-(1,2,3-triazol-1-yl)-pyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

関与物質

反応手順

Prepared by following the same procedure as described for Example 17 by using 5-amino-1-(2,4-difluorophenyl) -6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and cis-3-amino-4-(1,2,3-triazol-1-yl)-pyrrolidine. Yield: 66%, m.p. 279°-281° C. 1H NMR (TFA) δ: 4.48-4.82 (m, 4H), 5.02 (m, 1H), 6.26 (m, 1H), 7.17 (m, 2H), 7.62 (m, 1H), 8.6 (s, 1H), 8.82 (d, 2H).

情報源と証拠