Water → 1-Benzyl-4-(4-isopropylbenzoyl)piperidine

HRID 1743198ノート

反応式

HRID 1743198 の反応式
[CH:1]([C:4]1[CH:17]=[CH:16][C:7]([C:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:24](Br)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.O>CN(C)C=O>[CH2:24]([N:13]1[CH2:14][CH2:15][CH:10]([C:8](=[O:9])[C:7]2[CH:16]=[CH:17][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

6

反応物 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 222382884-[4-(Propan-2-yl)benzoyl]piperidine

生成物 1

HCID 219613551-Benzyl-4-(4-isopropylbenzoyl)piperidine収率 66%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-(4-isopropylbenzoyl)piperidine in N,N-dimethylformamide (100 mL), potassium carbonate (9.60 g, 69.5 mmol) and benzyl bromide (8.50 g, 71.5 mmol) were added, and the resulting mixture was stirred for 20 hours at room temperature. The mixture was poured into water, and extracted twice with ethyl acetate. The organic layers were combined, washed with an aqueous saturated sodium hydrogencarbonate, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was crystallized from hexane to obtain the title compound (13.53 g, yield 66%).

後処理

  1. extractionextracted twice with ethyl acetate
  2. washwashed with an aqueous saturated sodium hydrogencarbonate
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was crystallized from hexane

出典と根拠

ORDレコード
ord-ad5566352c4f4a43b9d587608d1e9f99
出典データセット
uspto-grants-2006_03
特許番号
US07008950B1

反応ノート

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