Hydrochloric Acid → HCID 22238060、化合物

HRID 1743400ノート

反応式

HRID 1743400 の反応式
[OH:1][C:2]1[C:3]([CH2:16][C:17]([CH3:19])=[CH2:18])=[C:4]2[C:8](=[C:9]([CH3:12])[C:10]=1[CH3:11])[N:7](C=O)[CH:6]([CH3:15])[CH2:5]2.[ClH:20]>C(O)C>[ClH:20].[CH3:18][C:17]1([CH3:19])[O:1][C:2]2[C:3](=[C:4]3[C:8](=[C:9]([CH3:12])[C:10]=2[CH3:11])[NH:7][CH:6]([CH3:15])[CH2:5]3)[CH2:16]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22238093HCID 22238093、化合物

生成物 1

HCID 22238060HCID 22238060、化合物収率 52%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,3-dihydro-5-hydroxy-2,6,7-trimethyl-4-(2-methyl-2-propen-1-yl)-1H-indole-1 carbaldehyde (0.26 g, 1.0 mmol) in ethanol (3 mL) was added concentrated hydrochloric acid (0.5 mL), and the mixture was heated to reflux for 1 hour. The reaction mixture was treated with active carbon, filtered, and concentrated under reducer pressure. The residue was recrystallized from ethanol-diethyl ether to obtain 0.14 g of the title compound.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 1 hour
  3. additionThe reaction mixture was treated with active carbon
  4. filtrationfiltered
  5. concentrationconcentrated under reducer pressure
  6. customThe residue was recrystallized from ethanol-diethyl ether

出典と根拠

ORDレコード
ord-a325b5ef695b49e4a102fa7c266b744c
出典データセット
uspto-grants-2006_03
特許番号
US07008940B1

反応ノート

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