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2-Fluoroethyl bromide → 2-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoroethyl bromide | HCID 12982 | — |
| 反応物 | 2-((4-Chlorophenyl)methyl)propanedinitrile | HCID 18082 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile | HCID 22235083 | 24.2% |
反応手順
Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-di-methylformamide, 0.21 g of sodium hydride (60% in oil), and 0.67 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.30 g of 2-(4-chlorobenzyl)-2-(2-fluoroethyl)malononitrile (the present compound (24)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07011838B2 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-4d5cb6f0d1f6400e874a20bd787e4215 |
| 出典メモ | uspto-grants-2006_03 |