Hydrochloric Acid → 4-[2-(3,8-Diazabicyclo[3.2.1]oct-8-yl)ethoxy]benzonitrile

HRID 1743721ノート

反応式

HRID 1743721 の反応式
[C:1]([C:3]1[CH:26]=[CH:25][C:6]([O:7][CH2:8][CH2:9][N:10]2[CH:15]3[CH2:16][CH2:17][CH:11]2[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14]3)=[CH:5][CH:4]=1)#[N:2].Cl>C(OCC)(=O)C>[CH:15]12[N:10]([CH2:9][CH2:8][O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:26][CH:25]=3)[CH:11]([CH2:17][CH2:16]1)[CH2:12][NH:13][CH2:14]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22235539Tert-butyl 8-[2-(4-cyanophenoxy)ethyl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate

生成物 1

HCID 222356414-[2-(3,8-Diazabicyclo[3.2.1]oct-8-yl)ethoxy]benzonitrile収率 73%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

反応条件

温度
0 °C

実験手順

tert-Butyl 8-[2-(4-Cyanophenoxy)ethyl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (1.35 g, 3.8 mmol; from step (b) above) was dissolved in ethyl acetate (30 mL). The solution was cooled to 0° C., ethyl acetate (30 mL) saturated with gaseous HCl was added, and the resulting mixture stirred at r.t for 15 h. The solvent was evaporated before CHCl3 was added. The mixture was extracted with K2CO3 solution, separated, dried and evaporated to give 0.7 g (73%) of the title compound.

後処理

  1. customThe solvent was evaporated before CHCl3
  2. additionwas added
  3. extractionThe mixture was extracted with K2CO3 solution
  4. customseparated
  5. customdried
  6. customevaporated

出典と根拠

ORDレコード
ord-0eb0e1f6ff0345b1ab5e5787fccf8f6f
出典データセット
uspto-grants-2006_03
特許番号
US07012074B2

反応ノート

読み込み中…