Ammonium Hydroxide → 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile

HRID 1743732ノート

反応式

HRID 1743732 の反応式
[O:1]1[CH2:3][C@@H:2]1[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.[NH4+:14].[OH-]>C(O)(C)C>[NH2:14][CH2:3][C@@H:2]([OH:1])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 6934186(R)-4-(Oxiran-2-ylmethoxy)benzonitrile

生成物 1

HCID 300720964-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile収率 91%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

4-[(2R)-Oxiranylmethoxy]benzonitrile (14.65 g, 83.6 mmol; prepared as described in international patent application WO 99/31100) was mixed with conc. NH4OH (64 mL) and 87 mL of isopropanol. The mixture was stirred at r.t for 18 h. The reaction mixture was filtered and the filtrate evaporated to give 14.6 g (91%) of the sub-title compound.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-2898c09fcc9b474dbeffd4f6f392d00f
出典データセット
uspto-grants-2006_03
特許番号
US07012074B2

反応ノート

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