Ethanol → HCID 22236953、化合物
反応式
[CH3:1][C:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)([CH2:9][N+:10]([O-])=O)[CH2:3][C:4](OCC)=O.C1(C)C=CC=CC=1.C([OH:28])C>[Ni]>[CH3:1][C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[C:3](=[O:28])[CH2:4][NH:10][CH2:9]1参加物
5
実験手順
A solution of 5.9 g of the compound obtained in Step 2 in 150 ml of ethanol was hydrogenated for 12 hours in the presence of 0.6 g of Raney nickel (10% w/w) under a hydrogen gas pressure of 60 psi. After the reaction was completed, the reaction solution was filtered with Celite® 545 and the filtrate was concentrated under reduced pressure. To the residue thus obtained was added 150 ml of toluene, and the resulting mixture was heated to reflux for 2 hours. The reaction product solution was concentrated under reduced pressure, and the residue thus obtained was purified by a silica gel column chromatography using a mixture of ethyl acetate and methanol of 9:1 to obtain 3.35 g of the title compound as a white solid.