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Quinaldic Acid → 3-Benzyloxy-6-(2-propyloxy)quinoline-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Quinaldic Acid | HCID 7124 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | O-benzylglycine toluene-p-sulphonate | HCID 6451311 | — |
| 反応物 | Ethylacetate heptane | HCID 21899848 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Benzyloxy-6-(2-propyloxy)quinoline-2-carboxylic acid | HCID 53779731 | 129.7% |
反応手順
2.7 g (8 mmol) of the above quinolinecarboxylic acid were reacted with 2.7 g (8 mmol) of glycine benzyl ester tosylate, 4.4 ml (32 mmol) of NEM, 1.35 g (10 mmol) of HOBT and 3.6 g (8.8 mmol) of CMC in 300 ml of anhydrous methylene chloride at 20° C. for 24 hours, analogously to Example 25g). After working up and chromatography over silica gel with n-heptane/ethyl acetate (3:2), 3.5 g of oily product were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726305 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-dd95acbc02174382a8fb617b567ae3bb |
| 出典メモ | uspto-grants-1998_03 |