Acetone → 4-Thiazolidinecarboxamide, 2,2,5,5-tetramethyl-

HRID 1744198ノート

反応式

HRID 1744198 の反応式
[NH2:1][C@H:2]([C:7]([NH2:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].[CH3:10][C:11]([CH3:13])=O>O>[CH3:10][C:11]1([CH3:13])[NH:1][CH:2]([C:7]([NH2:9])=[O:8])[C:3]([CH3:5])([CH3:4])[S:6]1

参加物

4

反応物 2

HCID 180AcetoneHCID 22797962HCID 22797962、化合物

生成物 1

HCID 101713024-Thiazolidinecarboxamide, 2,2,5,5-tetramethyl-収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Penicillaminamide (74.0 g, 0.50 mol) was dissolved in distilled water (800 ml) and added with acetone (58.0 g, 1.00 mol). The mixture was allowed to react at 30° C. for 1 hour with stirring under normal pressure and cooled. Then, water and acetone were evaporated by using an evaporator. The residue was washed with acetone to obtain white crystals (86.5 g, 0.46 mol) of 2,2,5,5-tetramethyl-1,3-thiazolidine-4-carboxylic acid amide. The yield to penicillaminamide was 92.0 mole %.

後処理

  1. customto react at 30° C. for 1 hour
  2. temperaturecooled
  3. customThen, water and acetone were evaporated
  4. customan evaporator
  5. washThe residue was washed with acetone

出典と根拠

ORDレコード
ord-7cc397e97fa94300a9b9a914ee20807c
出典データセット
uspto-grants-2006_03
特許番号
US07015029B2

反応ノート

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