関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dibenz(b,f)azepine | HCID 9212 | — |
| 反応物 | Sodium Cyanate | HCID 517096 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Carbamazepine | HCID 2554 | 80.3% |
反応手順
30 g iminostilbene are heated to 60° C. in 360 ml acetic acid and 50 ml ethanol, and 20 g 98% sodium cyanate is added within 1.5 hours at this temperature. After a short heating to 80° C., the mixture is further stirred at 60° C., and then cooled to 15° C., sucked off, washed with 20 l acetic acid and dried to yield 29.4 g (80.3% of theoretical) of carbamazepine, having a melting point of 189° C. to 192° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07015322B1 |
|---|
| 出典データセット | uspto-grants-2006_03 |
|---|
| ORD ID | ord-25819033458c4515bfe6d3a3aa574b2d |
|---|
| 出典メモ | uspto-grants-2006_03 |
|---|
