2-Propenoic acid, 2-(acetyloxy)-, methyl ester → (S)-methyl 2-methylcarbonyloxypropanoate

HRID 1744413

反応式

HRID 1744413 の反応式
[C:1]([O:4][C:5](=[CH2:10])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[H][H]>[B-](F)(F)(F)F.C1C2C=CC1C=C2.C1C2C=CC1C=C2.[Rh].PP.CO>[CH3:2][C:1]([O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7])=[O:3]

参加物

6

反応物 2

HCID 111372772-Propenoic acid, 2-(acetyloxy)-, methyl esterHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11051803(S)-methyl 2-methylcarbonyloxypropanoate

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 139283Diphosphane溶媒HCID 10915722Bis(norbornadiene)rhodium(I) tetrafluoroborate溶媒

実験手順

In a 50 ml Schlenk vessel, Rh(nbd)2BF4 (5.2 mg, 1 mol %) and the diphosphine ligand (1 mol %) were dissolved in MeOH (10 ml) under argon. After all of the rhodium complex had gone into solution, methyl 2-acetoxyacrylate (200 mg, 1.39 mmol) was added. The Schienk vessel was subsequently connected via a three-way stopcock with a hydrogen balloon and an oil pump and the inert gas atmosphere was replaced by hydrogen. The reaction mixture was stirred at room temperature for 20 h and the solvent was then distilled off in an oil pump vacuum. The residue was purified by bulb tube distillation. The ester (S)-8 was obtained as a colorless oil in quantitative yield.

後処理

  1. additionwas added
  2. distillationthe solvent was then distilled off in an oil pump vacuum
  3. customThe residue was purified by bulb tube
  4. distillationdistillation

出典と根拠

ORDレコード
ord-0489fe46fcc448b680af3d1bea2f9f8d
出典データセット
uspto-grants-2006_03
特許番号
US07015342B2

関連ノート

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