Piperidine → 5-Nitro-2-(piperidin-1-yl)benzonitrile

HRID 1744495ノート

反応式

HRID 1744495 の反応式
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(O)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]

参加物

4

反応物 2

HCID 8082PiperidineHCID 855042-Chloro-5-nitrobenzonitrile

生成物 1

HCID 48111995-Nitro-2-(piperidin-1-yl)benzonitrile収率 67.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Chloro-5-nitrobenzonitrile (20 g) and piperidine (9.34 g) were added to ethanol (100 ml) and the mixture was stirred at a refluxing temperature for 1 h. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from hydrous ethanol to give 5-nitro-2-piperidinobenzonitrile (17 g), melting point 75° C.

後処理

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the residue
  3. customcrystallization
  4. customThe crystals were recrystallized from hydrous ethanol

出典と根拠

ORDレコード
ord-7452868fd7284777b5f6b3c5e52dd31f
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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