Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester → 5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid

HRID 1744537ノート

反応式

HRID 1744537 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.C(O[CH:16]=[C:17]([C:23]([CH3:25])=O)[C:18]([O:20]CC)=[O:19])C>>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:23]([CH3:25])=[C:17]([C:18]([OH:20])=[O:19])[CH:16]=[N:10]2)=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 97734Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl esterHCID 1362004-(Trifluoromethyl)phenylhydrazine

生成物 1

HCID 107784295-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid収率 68.9%

実験手順

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 1 using 4-trifluoromethylphenylhydrazine (12.8 g) and ethyl 2-ethoxymethyleneacetoacetate (12.3 g), the title compound (12.3 g) was obtained, melting point: 181° C.

後処理

  1. customBy the reaction and treatment in the same manner as

出典と根拠

ORDレコード
ord-13ba6891e72e4bc0af0e60a030a9b061
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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