化工社化工社 化学情報印刷レポート · 研究参考用
1-(3-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(3-Chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid | HCID 4423672 | — |
| 反応物 | 5-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile | HCID 21942389 | — |
| 生成物 | 1-(3-Chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide | HCID 22227854 | 23.6% |
反応手順
By the reaction and treatment in the same manner as in Example 64 using 1-(3-chlorophenyl)-5-methylpyrazole-4-carboxylic acid (2.0 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (2.4 g), the title compound (1.0 g) was obtained, melting point: 210° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07015218B1 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-e091ba7db13e4270a2132204a7dcd01b |
| 出典メモ | uspto-grants-2006_03 |