1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → 1-(4-Chlorophenyl)-N-[3,5-dichloro-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:22]=[C:23]([Cl:37])[C:24]=1[N:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[CH2:27][CH2:26]1)[NH2:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:21][C:20]3[CH:19]=[C:18]([Cl:17])[C:24]([N:25]4[CH2:26][CH2:27][CH:28]([N:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[CH2:29][CH2:30]4)=[C:23]([Cl:37])[CH:22]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.77 g) and 3,5-dichloro-4-(4-morpholinopiperidin-1-yl)aniline (1.0 g), the title compound (1.0 g) was obtained, melting point: 246–248° C.
出典と根拠
- ORDレコード
- ord-2fee88d6ada04206ba384847053f12fe
- 出典データセット
- uspto-grants-2006_03