Potassium Hydroxide → 3-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid

HRID 1744903ノート

反応式

HRID 1744903 の反応式
CN[C:3]([C:5]1[S:6][C:7]([CH3:19])=[C:8]([CH3:18])[C:9]=1[C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4].[OH-:20].[K+]>CO.O>[C:10]([C:9]1[C:8]([CH3:18])=[C:7]([CH3:19])[S:6][C:5]=1[C:3]([OH:20])=[O:4])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 110439513-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid methylamide

生成物 1

HCID 118213443-Benzoyl-4,5-dimethylthiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

A solution of 16a (0.281 g, 1.03 mmole) in methanol-water 1:1 containing 10% KOH was heated at reflux for 12 hours, neutralized and extracted with ethyl acetate. The solid after evaporation was crystallized from ethanol. Yield 0.19 g, 71%.

後処理

  1. temperatureat reflux for 12 hours
  2. extractionextracted with ethyl acetate
  3. customThe solid after evaporation
  4. customwas crystallized from ethanol

出典と根拠

ORDレコード
ord-695ca23028aa4b2a80f15cbfc9391ad7
出典データセット
uspto-grants-2006_03
特許番号
US07019027B2

反応ノート

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