HCID 394241、化合物 → 5-Methylimidazo[2,1-b]benzothiazole-2-methanol

反応式

[CH3:1][C:2]1[C:7]2[N:8]3[CH:13]=[C:12]([C:14](OCC)=[O:15])[N:11]=[C:9]3[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][C:2]1[C:7]2[N:8]3[CH:13]=[C:12]([CH2:14][OH:15])[N:11]=[C:9]3[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 394241HCID 394241、化合物

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 118168225-Methylimidazo[2,1-b]benzothiazole-2-methanol収率 69%

実験手順

5-methyl imidazo[2,1-b]-benzthiazole-2-methanol was prepared according to the procedure outlined in Example 1, (Step 2). Starting from ethyl 5-methylimidazo[2,1-b]-benzthiazole-2-carboxylate (5.2 g, 20 mmol) and LiAlH4 solution (22 ml, 0.5 M solution in THF), 3 g (69% yield) of the alcohol derivative was isolated as a brown solid. (M+H) 219.

後処理

custom5-methyl imidazo[2,1-b]-benzthiazole-2-methanol was prepared

出典と根拠

ORDレコード: ord-8e386c6f405a4141872e9b96093688e7
出典データセット: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07018997B2

反応ノート

読み込み中…

参加物