3-Bromo-1,2-oxazole → 1-(4,5-dihydroisoxazol-3-yl)-1H-1,2,4-triazole-3-carboxylic acid
反応式
Br[C:2]1[CH:6]=[CH:5][O:4][N:3]=1.C[O:8][C:9]([C:11]1[N:15]=[CH:14][NH:13][N:12]=1)=[O:10]>>[O:4]1[CH2:5][CH2:6][C:2]([N:13]2[CH:14]=[N:15][C:11]([C:9]([OH:10])=[O:8])=[N:12]2)=[N:3]1参加物
3
実験手順
1-(4,5-dihydroisoxazol-3-yl)-1H-1,2,4-triazole-3-carboxylic acid I-171a and I-171b were prepared using the analogous procedure to Example 35 except that racemic compound I-75 was used as the starting bromo-isoxazole and 1H-1,2,4-triazole-3-carboxylic acid methyl ester as the nucleophile Additionally, at some point during the course of the reaction or workup, the ester hydrolyzed to the corresponding acid. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M−H]−=356.6 m/z. Activity: C
後処理
- customduring the course of the reaction or workup
- customThese compounds can be separated
出典と根拠
- ORDレコード
- ord-7adede485c544c839a26c6e1342f94cb
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09149465B2
反応ノート
読み込み中…