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HRID 1746717作成日：2026年10月27日

N,4-Dimethylcyclohexanamine → N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide

https://huagongshe.com/reaction/1746717

反応式

関与物質

役割名称HCID仕込み量
反応物N,4-DimethylcyclohexanamineHCID 4962029—
反応物6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamideHCID 59447105—
生成物N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamideHCID 25182771—

反応手順

Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and N,4-dimethylcyclohexanamine (Enamine), the title compound was obtained as a mixture of cis-trans stereoisomers, as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09150519B2
出典データセットuspto-grants-2015_10
ORD IDord-5391c4b3de4842f0843773560565830f
出典メモuspto-grants-2015_10