[ClH:1].C([O:5][C:6](=[O:45])[C@H:7]([N:25]1[CH2:29][CH2:28][C@H:27]([NH:30][S:31]([C:34]2[S:38][C:37]([N:39]3[CH2:43][CH2:42][CH2:41][CH2:40]3)=[N:36][CH:35]=2)(=[O:33])=[O:32])[C:26]1=[O:44])[CH2:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[O:19][C:20]([F:23])([F:22])[F:21])[C:15]([NH2:24])=[N:14][CH:13]=[CH:12]2)CC.O>Cl>[ClH:1].[NH2:24][C:15]1[C:16]2[C:11](=[CH:10][C:9]([CH2:8][C@@H:7]([N:25]3[CH2:29][CH2:28][C@H:27]([NH:30][S:31]([C:34]4[S:38][C:37]([N:39]5[CH2:43][CH2:42][CH2:41][CH2:40]5)=[N:36][CH:35]=4)(=[O:33])=[O:32])[C:26]3=[O:44])[C:6]([OH:45])=[O:5])=[C:18]([O:19][C:20]([F:22])([F:21])[F:23])[CH:17]=2)[CH:12]=[CH:13][N:14]=1A solution of 600 mg (0.82 m.mole) of (R)-3-(1-Amino-7-trifluoromethoxy-isoquinolin-6-yl)-2-[(S)-2-oxo-3-(2-pyrrolidin-1-yl-thiazole-5-sulfonylamino)-pyrrolidin-1-yl]-propionic acid propyl ester hydrochloride (compound of example 3) in 20 ml of 1N hydrochloric acid is heated at 80° C. for 4 h. The reaction mixture is evaporated to dryness. The crude material is taken up in acetone, and the precipitate formed is filtered, washed with acetone and dried under vacuum. 510 mg of a white powder containing 1.7 moles of HCl and 2 moles of H2O are collected (90% yield)
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