Hydrochloric Acid → HCID 89560341、化合物

反応式

C([NH:8][C@@H:9]([C:18]([OH:20])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)(OC(C)(C)C)=O.O1CCOCC1.[ClH:27]>>[ClH:27].[NH2:8][C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)[C:18]([OH:20])=[O:19]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 46737391N-((1,1-Dimethylethoxy)carbonyl)-3-iodo-D-phenylalanine

生成物 1

HCID 89560341HCID 89560341、化合物

実験手順

A solution of Boc-3-iodo-D-phenylalanine (5 g, 12.8 mmol, available from Matrix Scientific and 3BSC) in 4M HCl in dioxane (63.9 mL, 256 mmol) under argon was stirred at RT for 15 h. The resulting suspension was filtered, washed with Et2O and dried in vacuo to give the title compound as a white solid. LC-MS B: tR=0.42 min; [M+H]+=291.98.