Hydrochloric Acid → 1-(5-Chloro-1,2,3-trimethyl-1H-indol-7-ylmethyl)-5-methyl-1,3-dihydro-benzimidazol-2-one

To a solution of 1-(5-Chloro-1,2,3-trimethyl-1H-indol-7-ylmethyl)-3-isopropenyl-5-methyl-1,3-dihydro-benzimidazol-2-one (60 mg, 0.15 mmol) in a mixture of MeOH (3 mL) and water (3 mL), was added 1N HCl (2 mL). The reaction mixture was heated to 60° C. for 2 h. When the reaction was completed, the mixture was extracted with CH2Cl2 (×2). The organic phase was dried over Na2SO4 and concentrated to afford 40 mg of the desired product. The resulting residue was used for the next reaction without further purification.

1. extractionthe mixture was extracted with CH2Cl2 (×2)
2. dry with materialThe organic phase was dried over Na2SO4
3. concentrationconcentrated

ORDレコード

ord-8c202d327409420a9f1a5dbd969b9d24

出典データセット

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09150556B2