Hydrochloric Acid → HCID 59497358、化合物

HRID 1747349ノート

反応式

HRID 1747349 の反応式
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8](C(C)=C)[C:7]1=[O:18].Cl>C(O)C.O.ClCCl>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:18]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 59497548HCID 59497548、化合物

生成物 1

HCID 59497358HCID 59497358、化合物収率 86.4%

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒2 回HCID 6344Dichloromethane溶媒

反応条件

温度
60 °C

実験手順

To a stirred solution of 3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzimidazol-1-yl)-propionic acid methyl ester (4.8 g, 18.4 mmol) in ethanol (30 ml) and water (30 ml) was added 37% hydrochloric acid (24 ml). The resulting solution was warmed to 60° C. for twenty minutes and cooled. The reaction was diluted with dichloromethane and water. The layers were separated and the organic phase was dried (Na2SO4), filtered and concentrated to give 3.5 g (86%) of the desired product as an oil which solidified on standing. Used without further purification.

後処理

  1. temperaturecooled
  2. customThe layers were separated
  3. dry with materialthe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-c0a89cf2edb14a2bbeb4955d9e7b8a24
出典データセット
uspto-grants-2015_10
特許番号
US09150556B2

反応ノート

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