1-1,2-Benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one → 1-1,2-Benzisoxazol-3-ylmethyl-1,3-dihydro-benzimidazol-2-one

HRID 1747356ノート

反応式

HRID 1747356 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13](C(C)=C)[C:12]2=[O:23])=[N:2]1>C(O)C.O.Cl>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[NH:13][C:12]2=[O:23])=[N:2]1

参加物

5

反応物 1

HCID 594976931-1,2-Benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one

生成物 1

HCID 594976021-1,2-Benzisoxazol-3-ylmethyl-1,3-dihydro-benzimidazol-2-one収率 89%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒HCID 962Water溶媒2 回

反応条件

温度
60 °C

実験手順

The 1-1,2-benzisoxazol-3-ylmethyl-3-isopropenyl-1,3-dihydro-benzimidazol-2-one (0.26 g, 0.85 mmol) was diluted with ethanol (2 ml), water (2 ml) and 37% HCl (1 ml). The resulting mixture was warmed to 60° C. for 1 h and cooled to ambient temperature. The reaction was diluted with water and the product was extracted into dichloromethane. The layers were separated and the organic phase was dried (MgSO4). Filtration and concentration gave 0.20 g (89%) of the desired product which was used without further purification.

後処理

  1. temperaturecooled to ambient temperature
  2. extractionthe product was extracted into dichloromethane
  3. customThe layers were separated
  4. dry with materialthe organic phase was dried (MgSO4)
  5. filtrationFiltration and concentration

出典と根拠

ORDレコード
ord-88f96f7bd5d4421e9a825a9a6eb958e6
出典データセット
uspto-grants-2015_10
特許番号
US09150556B2

反応ノート

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