Hydrochloric Acid → HCID 178458491、化合物
反応式
[ClH:1].[OH:2][C:3]1([C:29]([F:32])([F:31])[F:30])[CH2:8][C:7](=[O:9])[NH:6][C:5]2[NH:10][N:11]=[C:12]([CH:13]3[CH2:18][CH2:17][N:16]([C:19]4[N:20]=[N:21][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:23][CH:24]=4)[CH2:15][CH2:14]3)[C:4]1=2>C(O)C>[ClH:1].[OH:2][C:3]1([C:29]([F:30])([F:31])[F:32])[CH2:8][C:7](=[O:9])[NH:6][C:5]2[NH:10][N:11]=[C:12]([CH:13]3[CH2:18][CH2:17][N:16]([C:19]4[N:20]=[N:21][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:23][CH:24]=4)[CH2:15][CH2:14]3)[C:4]1=2参加物
4
実験手順
1 N hydrochloric acid (0.295 mL, 0.295 mmol) was added dropwise at room temperature to a suspension of 4-hydroxy-3-{1-[6-(propan-2-yloxy)pyridazin-3-yl]piperidin-4-yl}-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (100 mg, 0.227 mmol) produced in Example 17 in ethanol (2 mL). Then, the solvent in the reaction solution was distilled off under reduced pressure. THF was added to the obtained residue, and the resulting suspension was stirred. The resulting precipitate was collected by filtration to obtain the title compound (88.0 mg, 81%).