関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 4-Bromo-2-fluorophenol | HCID 2724981 | — |
| 反応物 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Bromo-2-fluoro-1-isopropoxybenzene | HCID 2773389 | 107.4% |
反応手順
To a solution of 4-bromo-2-fluorophenol (10 g, 52.35 mmol) in THF (100 ml), isopropyl alcohol (4.8 ml, 62.62 mmol) and triphenylphosphine (20.6 g, 78.52 mmol) were added and heated to 45° C. followed by diisopropylazodicarboxylate (15.4 ml, 78.52 mmol). The mixture was refluxed for 1 h, concentrated and the residue was purified by column chromatography with ethyl acetate: petroleum ether to afford the title compound as a colourless liquid (13.1 g, 99%) which was used without purification in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09150579B2 |
|---|
| 出典データセット | uspto-grants-2015_10 |
|---|
| ORD ID | ord-8de0e36054f94005b8009b2fdd8cb849 |
|---|
| 出典メモ | uspto-grants-2015_10 |
|---|
